Posts

Remote Inflammatory Preconditioning Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Intrinsic Apoptosis in Rats

Image
Acute lung injury (ALI) always leads to severe inflammation. Since inflammation and oxidative stress are the common pathological basis for endotoxin-induced inflammatory injury and ischemic reperfusion injury (IRI), we speculate that remote ischemic preconditioning (RIPC) may be protective for ALI when used as inflammatory preconditioning. remote (RInPC). Method. A total of 21 SpragueDawley rats were used for the animal experiments. Eighteen rats were evenly and randomly divided into the control group (NS injection), LPS (LPS injection) and the RInPC group. RInPC was performed by tourniquet blocking of blood flow to the right hind paw prior to LPS injection and comprised three 5-minute binding cycles followed by 5-minute loosening. The animals were sacrificed 24 hours later. There were 2 rats in the LPS group and 1 in the RInPC group that died before the end of the experiment. Complementary experiments were performed on the LPS and RInPC groups to ensure that 6 animals in each group re

mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials

Image
Two double-blind, placebo-controlled, randomized phase 1 clinical trials recruited participants from single centers in Germany (H10N8) and the United States (H7N9) from December 2015 to August 2017. Participation of healthy adults (18 to 64 years old for study H10N8; 18 to 49 years old for study H7N9). Participants received the vaccine or placebo in a series of 2 doses 3 weeks apart. H10N8 intramuscular (IM) dose levels of 25, 50, 75, 100, and 400 µg and intradermal dose levels of 25 and 50 µg were evaluated. The dose levels of H7N9 IM 10, 25, and 50 µg were evaluated; a 2-dose series separated by 6 months was also evaluated. The primary endpoints are safety (adverse events) and tolerability. Secondary immunogenicity results include humoral reactions (hemagglutination inhibition [HAI], microneutralization [MN]) and cell-mediated reactions. The H10N8 and H7N9 mRNA IM vaccines showed good safety and reactogenic  characteristics. No serious adverse event s related to the vaccine were

A Brighton Collaboration standardized template with key considerations for a benefit/risk assessment for a soluble glycoprotein vaccine to prevent disease caused by Nipah or Hendra viruses

Image
                                             vaccines LLC has developed a protein vaccine to prevent diseases caused by Nipah and Hendra virus infections, which uses recombinant soluble Hendra glycoprotein (HeVsG) adulated with aluminum phosphate. The vaccine is currently under clinical evaluation in a phase 1 study. The Technical Working Group (BRAVATO; exV3SWG) has prepared a standardized template for the risk assessment of the benefits of vaccines to describe the key considerations for the evaluation of risks of the benefits of protein vaccines. This will help key stakeholders assess potential safety issues and understand the profit risk of such vaccine platforms. The structured and standardized evaluation provided by the staff can also help increase public acceptance and communication of licensed protein vaccines. Protein vaccines usually contain viral surface antigens that are responsible for stimulating neutralizing antibodies. They are usually recombinant and highly purified. Pe

Childhood immunization during the COVID-19 pandemic in Texas

Image
  In 2020, the state of Texas implemented  coronavirus disease 2019  (COVID-19) social distancing guidelines in order to prevent surges at Texas hospital emergency rooms and in intensive care units. As noted in other states, an unintended consequence of these activities was significant declines in childhood immunizations. After analyzing state-wide immunization register data for Texas, we observed a 47% relative decline in immunization rates between 2019 and 2020 among 5-month-olds and a 58% decline among 16-month-olds. We observed a small decline (5%) among 24-month-olds, and no decline in vaccines received at birth (Hepatitis B). Declines were larger in rural counties compared to urban. These declines are superimposed on increases in state vaccine exemptions over the last five years due to an aggressive anti-vaccine movement in Texas. There are concerns that continued declines in childhood  immunization coverage  due to COVID-19 could lead to co-endemics of  measles  and other vaccin
Image
  Submit your abstracts now.... URL: https:// vaccinesworld.insightconferences.com Mail: vaccinesworld@medicalscienceconference.com #Vaccines #Pediatric #HIV #Toxoid #DNA #Synthetic #Immunology Register now..